Max Planck Institute for Biophysical Chemistry

Emerging Topics in Biomolecular Magnetic Resonance

Emerging Topics in Biomolecular Magnetic Resonance

Presenting frontier research in magnetic resonance in biological systems

Organized by

Loren Andreas, Stefan Glöggler, Christian Griesinger, Mei Hong, Óscar Millet, Arthur G. Palmer, Markus Zweckstetter

Weekly on Thursday

7 a.m. PST (San Francisco) / 10 a.m. EST (New York) / 4 p.m. CST (Berlin) / 7.30 p.m IST (India) / 10 p.m. CST (Peking)

Register here for the Online Seminar

Register here for the Online Seminar

Online Seminar

Thursday, 21^th of January 2021

<p>Membrane Interactions of 40-Residue Beta-Amyloid Peptides</p>

Membrane Interactions of 40-Residue Beta-Amyloid Peptides

Wei Qiang (Binghamton University)

<p><sup>1</sup>H-detected solid-state NMR as an access to µs timescale conformational dynamics in large enzymes</p>

¹H-detected solid-state NMR as an access to µs timescale conformational dynamics in large enzymes

Rasmus Linser (Technical University Dortmund)

Thursday, 14^th of January 2021

<p>Transient structure in IDPs from 3D NUS NMR of chemical denaturation</p>

Transient structure in IDPs from 3D NUS NMR of chemical denaturation

Ad Bax (NIDDK/NIH)

<p>Time Travel to the Past and Future – Evolution of energy landscapes for enzymes catalysis</p>

Time Travel to the Past and Future – Evolution of energy landscapes for enzymes catalysis

Dorothee Kern (Brandeis University)

Thursday, 10^th of December 2020

<p>Structures of SARS-CoV-2 & Influenza Viroporins: a Quest to Block Pandemics</p>

Structures of SARS-CoV-2 & Influenza Viroporins: a Quest to Block Pandemics

Mei Hong (MIT, Cambridge MA)

more

<p>Biomolecular condensation: from transcription to SARS-CoV-2</p>

Biomolecular condensation: from transcription to SARS-CoV-2

Markus Zweckstetter (DZNE/MPIBPC, Göttingen)

more

Thursday, 3^rd of December 2020

<p>Nanoparticle-assisted NMR spin relaxation: a new window into biomolecular interactions and dynamics</p>

Nanoparticle-assisted NMR spin relaxation: a new window into biomolecular interactions and dynamics

Rafael Brüschweiler (The Ohio State University)

<p>Tracking the evolution of tau in solution, droplet and fibril states</p>

Tracking the evolution of tau in solution, droplet and fibril states

Songi Han (UC Santa Barbara)

Thursday, 26^th of November 2020

<p>Just flexible linkers? Un-structural biology by NMR</p>

Just flexible linkers? Un-structural biology by NMR

Roberta Pierattelli (University of Florence/CERM)

<p>Factor X interaction with Ixolaris reveals a noncanonical mechanism of Kunitz inhibition</p>

Factor X interaction with Ixolaris reveals a noncanonical mechanism of Kunitz inhibition

Ana Paula Valente (Federal University of Rio de Janeiro)

Thursday, 19^th of November 2020

<p>ALIX in Wonderland: Multivalency and Phosphorylation-mediated Reversible Amyloids Studied by Solution NMR Spectroscopy</p>

ALIX in Wonderland: Multivalency and Phosphorylation-mediated Reversible Amyloids Studied by Solution NMR Spectroscopy

Lalit Deshmukh (University of California San Diego)

<p>Lipid regulation of a K+ channel viewed by solid-state NMR</p>

Lipid regulation of a K+ channel viewed by solid-state NMR

Benjamin J. Wylie (Texas Tech University)

Thursday, 12^th of November 2020

High-resulution NMR ob biomulecules, large and small, over orders of magnitude of magnetic fields

High-resulution NMR ob biomulecules, large and small, over orders of magnitude of magnetic fields

Fabien Ferrage (CNRS) more

Solid-state NMR approaches for cellular structural biology

Solid-state NMR approaches for cellular structural biology

Marc Baldus (Utrecht University) more

Thursday, 5^th of November 2020

<p>Eavesdropping on the Cellular Adventures of a Pathogenic Cytotoxin</p>

Eavesdropping on the Cellular Adventures of a Pathogenic Cytotoxin

Jordan Chill (Bar Ilan University)

more

<p>Integrated Structural Biology of HIV-1 Assemblies</p>

Integrated Structural Biology of HIV-1 Assemblies

Tatyana Polenova (University of Delaware)

Thursday, 29^th of October 2020

<p>Structure and function of biomolecules by detecting nuclear spins with EPR</p>

Structure and function of biomolecules by detecting nuclear spins with EPR

Marina Bennati (Max Planck Institute for Biophysical Chemistry)

<p>Mechanisms of Action for Pathogenic Mutations in the FGF Receptor Kinase</p>

Mechanisms of Action for Pathogenic Mutations in the FGF Receptor Kinase

Nathaniel Traaseth (New York Frankfurt)

more

Thursday, 22^nd of October 2020

Dynamic regulation of client and cochaperone interactions of Hsp90

Dynamic regulation of client and cochaperone interactions of Hsp90

Michael Sattler (Helmholtz Center & Technical University Munich)

Time-resolved solid state NMR of biomolecular self-assembly processes

Time-resolved solid state NMR of biomolecular self-assembly processes

Robert Tycko (NIDDK, National Institutes of Health) more

Thursday, 15^thof October 2020

<p>Turning peptide toxins into therapeutics: the importance of structure AND dynamics</p>

Turning peptide toxins into therapeutics: the importance of structure AND dynamics

Raymond Norton (Monash University)

<p>Protein (mis)folding at high sensitivity and resolution</p>

Protein (mis)folding at high sensitivity and resolution

Henrike Heise (Forschungszentrum Jülich)

more

Thursday, 5^th of October 2020

<span lang="EN-US">Beyond static structures: Linking conformational changes in enzymes with function</span>

Beyond static structures: Linking conformational changes in enzymes with function

Remco Sprangers (University of Regensburg) more

<span lang="EN-US">Innovations in Protein SSNMR using Ultra-fast MAS and SSNMR Studies on New Polymorphs of Ab42 Fibrils</span>

Innovations in Protein SSNMR using Ultra-fast MAS and SSNMR Studies on New Polymorphs of Ab42 Fibrils

Yoshitaka Ishii (Tokyo Institute of Technology & RIKEN)

Thursday, 1^st of October 2020

Interactions and dynamics of arginine side chains in proteins by <sup>13</sup>C-detected NMR

Interactions and dynamics of arginine side chains in proteins by ¹³C-detected NMR

Flemming D. Hansen (University College London) more

Structural architecture of yeast cell wall and functional amyloids by solid-state NMR

Structural architecture of yeast cell wall and functional amyloids by solid-state NMR

Antoine Loquet (Universite Bordeaux) more

Thursday, 24^th of September 2020

Finding order in disordered proteins

Finding order in disordered proteins

Robert Konrat (University of Vienna) more

The conformational equilibrium of the neuropeptide Y2 G protein-coupled receptor in membranes studied by solid-state NMR

The conformational equilibrium of the neuropeptide Y2 G protein-coupled receptor in membranes studied by solid-state NMR

Daniel Huster (Leipzig University) more

THURSDAY, 17^th of September 2020

<span lang="EN-US">Regulins control Ca<sup>2+</sup>-ATPase function via topological allostery</span>

Regulins control Ca²⁺-ATPase function via topological allostery

Gianluigi Veglia (University of Minnesota) more

<span lang="EN-US">Unveiling the “invisible” regulatory states in RNA</span>

Unveiling the “invisible” regulatory states in RNA

Qi Zhang (University of North Carolina at Chapel Hill)

THURSDAY, 10^th of September 2020

Proton detected experiments for structural characterization of biomolecules and a-synuclin fibril polymorphs from different aggregation intermediates

Proton detected experiments for structural characterization of biomolecules and a-synuclin fibril polymorphs from different aggregation intermediates

Vipin Agarwal (TIFR Hyderabad)

<p><span>NMR-guided fragment-to-lead evolution</span></p>

NMR-guided fragment-to-lead evolution

Ruan Ke (University of Science & Technology of China)

more

THURSDAY, 3^rd of September 2020

<p>Proton-detected solid-state NMR of viral protein assemblies</p>

Proton-detected solid-state NMR of viral protein assemblies

Anja Böckmann (University Lyon)

more

New CEST Experiments to study protein conformational exchange

New CEST Experiments to study protein conformational exchange

Pramodh Vallurupalli (Tata Institute of Fundamental Research)

more

THURSDAY, 27^th of August 2020

<p>NMR characterization of the structural E and S membrane proteins of SARS-CoV-2</p>

NMR characterization of the structural E and S membrane proteins of SARS-CoV-2

Sang Ho Park (University of California, San Diego)

more

<p>NMR studies of SARS-CoV-2 viral RNAs, proteins and their complexes and screening against viral targets</p>

NMR studies of SARS-CoV-2 viral RNAs, proteins and their complexes and screening against viral targets

Andreas Schlundt/Boris Fürtig (University Frankfurt)

more

THURSDAY, 20^th of August 2020

<p>Old wine in a new bottle: Repurposing 19F-NMR for biomolecules by combating the deleterious effects of CSA with TROSY</p>

Old wine in a new bottle: Repurposing 19F-NMR for biomolecules by combating the deleterious effects of CSA with TROSY

Haribabu Arthanari (Harvard Medical School)

more

<p>Resolving structure and functional dynamics of large protein complexes by solid-state NMR, cryo-EM and MD: from new methods to biological insight</p>

Resolving structure and functional dynamics of large protein complexes by solid-state NMR, cryo-EM and MD: from new methods to biological insight

Paul Schanda (Institut de Biologie Structurale, Grenoble)

more

THURSDAY, 13^th of August 2020

Structural rearrangement modulates the regulatory activity in CCCH-type zinc finger proteins

Structural rearrangement modulates the regulatory activity in CCCH-type zinc finger proteins

Francesca Massi (University of Massachusetts)

more

<p>Heteronuclear spin decoupling for all (commerical) MAS frequencies: Methods and recipes</p>

Heteronuclear spin decoupling for all (commerical) MAS frequencies: Methods and recipes

P. K. Madhu (TIFR Hyderabad)

more

THURSDAY, 6^th of August 2020

<p>The mystery of the double peak in the EPR spectrum of transferrin</p>

The mystery of the double peak in the EPR spectrum of transferrin

Guinevere Mathies (University of Konstanz)

more

<p>High pressure NMR: Squeezing out unique information on protein ligand binding and conformational changes</p>

High pressure NMR: Squeezing out unique information on protein ligand binding and conformational changes

Kevin Gardner (CUNY Advanced Science Research Center, New York)

more

THURSDAY, 30^th of July 2020

<p>MicroRNA dynamics by NMR: excited to see the invisible</p>

MicroRNA dynamics by NMR: excited to see the invisible

Katja Petzold (Karolinska Institute)

more

<p>Novel nanodiscs for NMR studies on membrane proteins</p>

Novel nanodiscs for NMR studies on membrane proteins

Ayyalusamy Ramamoorthy (University of Michigan)

more

THURSDAY, 23^rd of July 2020

<p>High-resolution NMR of antibiotics in cell membranes</p>

High-resolution NMR of antibiotics in cell membranes

Markus Weingarth (Utrecht University)

more

<p>NMR of highly disordered molecular assemblies involved in viral replication</p>

NMR of highly disordered molecular assemblies involved in viral replication

Martin Blackledge (Institut de Biologie Structurale Jean-Pierre Ebel, CEA, CNRS)

more

THURSDAY, 16^th of July 2020

<p>Solution NMR insights into phase separation of intrinsically disordered protein regions</p>

Solution NMR insights into phase separation of intrinsically disordered protein regions

Julie Forman-Kay (University of Toronto)

more

<p>MAS NMR studies of heterochromatin phase separation</p>

MAS NMR studies of heterochromatin phase separation

Galia Debelouchina (University of California, San Diego)

THURSDAY, 9^th of July 2020

<p>Spin state evolution during the biological water splitting reaction</p>

Spin state evolution during the biological water splitting reaction

Nick Cox (Australian National University)

more

<p>In cell structural biology enabled by DNP MAS NMR</p>

In cell structural biology enabled by DNP MAS NMR

Kendra Frederick (UT Southwestern)

more

THURSDAY, 2^nd of July 2020

<span>Structural equilibrium underlying ligand-dependent activation of GPCR</span>

Structural equilibrium underlying ligand-dependent activation of GPCR

Ichio Shimada (RIKEN Center for Biosystems Dynamics Research)

<span>A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR</span>

A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR

Anne Grahl (Biozentrum, University of Basel) more

THURSDAY, 25^th of June 2020

<span>Understanding extracellular matrix disease states with solid-state NMR?</span>

Understanding extracellular matrix disease states with solid-state NMR?

Melinda J. Duer (University of Cambridge) more

<span>NMR for metabolomics: again the 'second best' technique?</span>

NMR for metabolomics: again the 'second best' technique?

Claudio Luchinat (University of Florence) more

THURSDAY, 18^th of June 2020

<span>Elucidation of carbohydrate structure in plant biomass and fungal pathogens using solid-state NMR and DNP methods</span>

Elucidation of carbohydrate structure in plant biomass and fungal pathogens using solid-state NMR and DNP methods

Tuo Wang (Lousiana State University) more

Molecular chaperones in protein disaggregation - What can we learn from NMR

Rina Rosenzweig (Weizmann Institute of Sciencey)

THURSDAY, 11^th of June 2020

<span>Putative Amyloids in Human Health— Insights from NMR</span>

Putative Amyloids in Human Health— Insights from NMR

Ann E. McDermott (Columbia University) more

<span>An RNA dynamic ensemble at atomic resolution</span>

An RNA dynamic ensemble at atomic resolution

Hashim Al-Hashimi (Duke University) more

THURSDAY, 4^th of June 2020

<span>Mn(II) DEER tracks two ‘closed’ ATP-, ADP-dependent conformations in yeast Hsp90 chaperone</span>

Mn(II) DEER tracks two ‘closed’ ATP-, ADP-dependent conformations in yeast Hsp90 chaperone

Daniella Goldfarb (Weizmann Institute of Science) more

<span>NMR: The Big and the Invisible</span>

NMR: The Big and the Invisible

Lewis Kay (University of Toronto) more