Max Planck Institute for Biophysical Chemistry

Emerging Topics in Biomolecular Magnetic Resonance

Emerging Topics in Biomolecular Magnetic Resonance

Presenting frontier research in magnetic resonance in biological systems

Organized by

Loren Andreas, Stefan Glöggler, Christian Griesinger, Mei Hong, Óscar Millet, Arthur G. Palmer, Markus Zweckstetter

https://zoom.us/j/91219438807?pwd=NHZnbUZHZ1d0YW1YcStJU2t0dlBEdz09

Webinar-ID: 912 1943 8807, Password: bioNMR2020

Weekly on Thursday

7 a.m. PST (San Francisco) / 10 a.m. EST (New York) / 4 p.m. CEST (Berlin) / 7.30 p.m IST (India) / 10 p.m. CST (Peking)

Online Seminar

Thursday, 1^st of October 2020

Interactions and dynamics of arginine side chains in proteins by <sup>13</sup>C-detected NMR

Interactions and dynamics of arginine side chains in proteins by ¹³C-detected NMR

Flemming D. Hansen (University College London)

Structural architecture of yeast cell wall and functional amyloids by solid-state NMR

Structural architecture of yeast cell wall and functional amyloids by solid-state NMR

Antoine Loquet (Universite Bordeaux)

Thursday, 24^th of September 2020

Finding order in disordered proteins

Finding order in disordered proteins

Robert Konrat (University of Vienna)

The conformational equilibrium of the neuropeptide Y2 G protein-coupled receptor in membranes studied by solid-state NMR

The conformational equilibrium of the neuropeptide Y2 G protein-coupled receptor in membranes studied by solid-state NMR

Daniel Huster (Leipzig University)

THURSDAY, 17^th of September 2020

<span lang="EN-US">Regulins control Ca<sup>2+</sup>-ATPase function via topological allostery</span>

Regulins control Ca²⁺-ATPase function via topological allostery

Gianluigi Veglia (University of Minnesota)

<span lang="EN-US">Unveiling the “invisible” regulatory states in RNA</span>

Unveiling the “invisible” regulatory states in RNA

Qi Zhang (University of North Carolina at Chapel Hill)

THURSDAY, 10^th of September 2020

Proton detected experiments for structural characterization of biomolecules and a-synuclin fibril polymorphs from different aggregation intermediates

Proton detected experiments for structural characterization of biomolecules and a-synuclin fibril polymorphs from different aggregation intermediates

Vipin Agarwal (TIFR Hyderabad)

<p><span>NMR-guided fragment-to-lead evolution</span></p>

NMR-guided fragment-to-lead evolution

Ruan Ke (University of Science & Technology of China)

THURSDAY, 3^rd of September 2020

<p>Proton-detected solid-state NMR of viral protein assemblies</p>

Proton-detected solid-state NMR of viral protein assemblies

Anja Böckmann (University Lyon)

New CEST Experiments to study protein conformational exchange

New CEST Experiments to study protein conformational exchange

Pramodh Vallurupalli (Tata Institute of Fundamental Research)

THURSDAY, 27^th of August 2020

<p>NMR characterization of the structural E and S membrane proteins of SARS-CoV-2</p>

NMR characterization of the structural E and S membrane proteins of SARS-CoV-2

Sang Ho Park (University of California, San Diego)

<p>NMR studies of SARS-CoV-2 viral RNAs, proteins and their complexes and screening against viral targets</p>

NMR studies of SARS-CoV-2 viral RNAs, proteins and their complexes and screening against viral targets

Andreas Schlundt/Boris Fürtig (University Frankfurt)

THURSDAY, 20^th of August 2020

<p>Old wine in a new bottle: Repurposing 19F-NMR for biomolecules by combating the deleterious effects of CSA with TROSY</p>

Old wine in a new bottle: Repurposing 19F-NMR for biomolecules by combating the deleterious effects of CSA with TROSY

Haribabu Arthanari (Harvard Medical School)

more

<p>Resolving structure and functional dynamics of large protein complexes by solid-state NMR, cryo-EM and MD: from new methods to biological insight</p>

Resolving structure and functional dynamics of large protein complexes by solid-state NMR, cryo-EM and MD: from new methods to biological insight

Paul Schanda (Institut de Biologie Structurale, Grenoble)

more

THURSDAY, 13^th of August 2020

Structural rearrangement modulates the regulatory activity in CCCH-type zinc finger proteins

Structural rearrangement modulates the regulatory activity in CCCH-type zinc finger proteins

Francesca Massi (University of Massachusetts)

more

<p>Heteronuclear spin decoupling for all (commerical) MAS frequencies: Methods and recipes</p>

Heteronuclear spin decoupling for all (commerical) MAS frequencies: Methods and recipes

P. K. Madhu (TIFR Hyderabad)

more

THURSDAY, 6^th of August 2020

<p>The mystery of the double peak in the EPR spectrum of transferrin</p>

The mystery of the double peak in the EPR spectrum of transferrin

Guinevere Mathies (University of Konstanz)

more

<p>High pressure NMR: Squeezing out unique information on protein ligand binding and conformational changes</p>

High pressure NMR: Squeezing out unique information on protein ligand binding and conformational changes

Kevin Gardner (CUNY Advanced Science Research Center, New York)

more

THURSDAY, 30^th of July 2020

<p>MicroRNA dynamics by NMR: excited to see the invisible</p>

MicroRNA dynamics by NMR: excited to see the invisible

Katja Petzold (Karolinska Institute)

more

<p>Novel nanodiscs for NMR studies on membrane proteins</p>

Novel nanodiscs for NMR studies on membrane proteins

Ayyalusamy Ramamoorthy (University of Michigan)

more

THURSDAY, 23^rd of July 2020

<p>High-resolution NMR of antibiotics in cell membranes</p>

High-resolution NMR of antibiotics in cell membranes

Markus Weingarth (Utrecht University)

more

<p>NMR of highly disordered molecular assemblies involved in viral replication</p>

NMR of highly disordered molecular assemblies involved in viral replication

Martin Blackledge (Institut de Biologie Structurale Jean-Pierre Ebel, CEA, CNRS)

more

THURSDAY, 16^th of July 2020

<p>Solution NMR insights into phase separation of intrinsically disordered protein regions</p>

Solution NMR insights into phase separation of intrinsically disordered protein regions

Julie Forman-Kay (University of Toronto)

more

<p>MAS NMR studies of heterochromatin phase separation</p>

MAS NMR studies of heterochromatin phase separation

Galia Debelouchina (University of California, San Diego)

THURSDAY, 9^th of July 2020

<p>Spin state evolution during the biological water splitting reaction</p>

Spin state evolution during the biological water splitting reaction

Nick Cox (Australian National University)

more

<p>In cell structural biology enabled by DNP MAS NMR</p>

In cell structural biology enabled by DNP MAS NMR

Kendra Frederick (UT Southwestern)

more

THURSDAY, 2^nd of July 2020

<span>Structural equilibrium underlying ligand-dependent activation of GPCR</span>

Structural equilibrium underlying ligand-dependent activation of GPCR

Ichio Shimada (RIKEN Center for Biosystems Dynamics Research)

<span>A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR</span>

A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR

Anne Grahl (Biozentrum, University of Basel) more

THURSDAY, 25^th of June 2020

<span>Understanding extracellular matrix disease states with solid-state NMR?</span>

Understanding extracellular matrix disease states with solid-state NMR?

Melinda J. Duer (University of Cambridge) more

<span>NMR for metabolomics: again the 'second best' technique?</span>

NMR for metabolomics: again the 'second best' technique?

Claudio Luchinat (University of Florence) more

THURSDAY, 18^th of June 2020

<span>Elucidation of carbohydrate structure in plant biomass and fungal pathogens using solid-state NMR and DNP methods</span>

Elucidation of carbohydrate structure in plant biomass and fungal pathogens using solid-state NMR and DNP methods

Tuo Wang (Lousiana State University) more

Molecular chaperones in protein disaggregation - What can we learn from NMR

Rina Rosenzweig (Weizmann Institute of Sciencey)

THURSDAY, 11^th of June 2020

<span>Putative Amyloids in Human Health— Insights from NMR</span>

Putative Amyloids in Human Health— Insights from NMR

Ann E. McDermott (Columbia University) more

<span>An RNA dynamic ensemble at atomic resolution</span>

An RNA dynamic ensemble at atomic resolution

Hashim Al-Hashimi (Duke University) more

THURSDAY, 4^th of June 2020

<span>Mn(II) DEER tracks two ‘closed’ ATP-, ADP-dependent conformations in yeast Hsp90 chaperone</span>

Mn(II) DEER tracks two ‘closed’ ATP-, ADP-dependent conformations in yeast Hsp90 chaperone

Daniella Goldfarb (Weizmann Institute of Science) more

<span>NMR: The Big and the Invisible</span>

NMR: The Big and the Invisible

Lewis Kay (University of Toronto) more