MPI Campus Seminar: Nuclear Singlet States. A phenomenon with possible applicability in MRI?

MPI Campus Seminar

  • Date: Dec 2, 2020
  • Time: 11:00 - 12:00
  • Speaker: Philip Saul
  • NMR Signal Enhancement Group
  • Location: Max-Planck-Institut für biophysikalische Chemie (MPIBPC)
  • Room: Online
  • Host: S. Glöggler, A. Godec, A. Faesen, J. Liepe, S. Meek, A. Stein, M. Wilczek, S. Karpitschka, D. Zwicker, M. Oudelaar, L. Andreas
  • Contact: stefan.gloeggler@mpibpc.mpg.de
MPI Campus Seminar: Nuclear Singlet States. A phenomenon with possible applicability in MRI?
Magnetic resonance imaging is an essential tool for medical diagnostics. However, in most standard applications, it is somewhat limited by the fact that the vast amount of signal arises from water. Direct observation of molecules other than water is, at least in proton-based experiments, hardly possible. Nuclear singlet states might be a way to circumvent this problem and make direct observation of non-water protons feasible. By transferring magnetization from the triplet state of a proton pair to the singlet state, thus storing magnetization, and transferring the magnetization back, suppression of any other proton signal can be achieved. By using modified dendrimers, a high density of those proton pairs can be made available in a small area. Furthermore an interesting behaviour of those dendrimers in the presence of metal ions has been observed, in that relaxation enhancing effects of paramagnetic ions seem to be absent in Fe(II), Gd(III) and Mn(II) whereas this effect can still be observed in the presence of Cu(II). Given the possible role of Cu(II) in neurodegenerative diseases such as Alzheimer’s, applications in early recognition of high Cu(II) concentrations and thus signs for said diseases, might be possible.
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