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Cellular Logistics

Transport processes between nucleus and cytoplasm


Press Releases & Research News

Researchers have developed mini-antibodies that efficiently block SARS-CoV-2 and its dangerous new variants. These so-called nanobodies bind and neutralize the virus up to 1000 times better than previously developed mini-antibodies. In addition, the scientists optimized their mini-antibodies for stability and resistance to extreme heat. This unique combination makes them promising agents to treat COVID-19. more

A research team involving Dirk Görlich of the MPI for Biophysical Chemistry has been awarded one of highly competetive Synergy Grants from the European Research Council. Funds of 11 million Euros during the next six years will enable the scientists to elucidate the molecular details of muscle formation and function. more


Logistics on smallest possible space: Transport processes between cell nucleus and cytoplasm
The cell nucleus is enclosed by the nuclear envelope, lacks protein synthesis and therefore imports each and every protein from the cytosol. Conversely, the nucleus supplies the cytoplasm with nuclear products, such as ribosomes, tRNAs and mRNAs. The permeability barrier of nuclear pore complexes controls all this exchange. This permeability barrier is an "intelligent" hydrogel with truly remarkable properties. It excludes inert macromolecules, but permits an up to 20 000-fold faster entry of cargoes, when these are bound to appropriate nuclear transport receptors. (in German) more
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