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Journal Article (87)

  1. Journal Article
    Prajapati, S.; Haselbach, D.; Wittig, S.; Patel, M. S.; Chari, A.; Schmidt, C.; Stark, H.; Tittmann, K.: Structural and functional analyses of the human PDH complex suggest a "Division-of-Labor" mechanism by local E1 and E3 clusters. Structure 27 (7), pp. 1124 - 1136 (2019)
  2. Journal Article
    Kastner, B.; Will, C. L.; Stark, H.; Lührmann, R.: Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology (2019)
  3. Journal Article
    Watson, E. R.; Brown, N. G.; Peters, J. M.; Stark, H.; Schulman, B. A.: Posing the APC/C E3 ubiquitin ligase to orchestrate cell division. Trends in Cell Biology 29 (2), pp. 117 - 134 (2019)
  4. Journal Article
    Renaud, J. P.; Chari, A.; Ciferri, C.; Liu, W.; Rémigy, H. W.; Stark, H.; Wiesmann, C.: Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery 17 (7), pp. 471 - 492 (2018)
  5. Journal Article
    Haselbach, D.; Komarov, I.; Agafonov, D. E.; Hartmuth, K.; Graf, B.; Dybkov, O.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Structure and conformational dynamics of the human spliceosomal Bact complex. Cell 172 (3), pp. 454 - 464, e1-e5 (2018)
  6. Journal Article
    Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 170 (4), pp. 701 - 713, e1 - e4 (2017)
  7. Journal Article
    Haselbach, D.; Schrader, J.; Lambrecht, F.; Henneberg, F.; Chari, A.; Stark, H.: Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nature Communications 8 (2017)
  8. Journal Article
    Rodnina, M. V.; Fischer, N.; Maracci, C.; Stark, H.: Ribosome dynamics during decoding. Philosophical Transactions of the Royal Society B 372 (1716), 20160182 (2017)
  9. Journal Article
    Bertram, K.; Agafonov, D. E.; Liu, W.; Dybkov, O.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), pp. 318 - 323 (2017)
  10. Journal Article
    Fischer, N.; Neumann, P.; Bock, l. V.; Maracci, C.; Wang, Z.; Paleskava, A.; Konevega, A. L.; Schröder, G. F.; Grubmüller, H.; Ficner, R. et al.; Rodnina, M. V.; Stark, H.: The pathway to GTPase activation of elongation factor SelB on the ribosome. Nature 540 (7631), pp. 80 - 85 (2016)
  11. Journal Article
    Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), pp. 1399 - 1405 (2016)
  12. Journal Article
    Paknia, E.; Chari, A.; Stark, H.; Fischer, U.: The ribosome cooperates with the assembly chaperone pICln to initiate formation of snRNPs. Cell Reports 16 (12) (2016)
  13. Journal Article
    Hons, M.; Huis in ‘t Veld, P. J.; Kaesler, J.; Rombaut, P.; Schleiffer, A.; Herzog, F.; Stark, H.; Peters, J. M.: Topology and structure of an engineered human cohesin complex bound to Pds5B. Nature Communications 7 (2016)
  14. Journal Article
    Yamaguchi, M.; VanderLinden, R.; Weissmann, F.; Qiao, R.; Dube, P.; Brown, N. G.; Haselbach, D.; Zhang, W.; Sidhu, S. S.; Peters, J. M. et al.; Stark, H.; Schulman, B. A.: Cryo-EM of mitotic checkpoint complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation. Molecular Cell 63 (4), pp. 593 - 607 (2016)
  15. Journal Article
    Schrader, J.; Henneberg, F.; Mata, R. A.; Tittmann, K.; Schneider, T. R.; Stark, H.; Bourenkov, G.; Chari, A.: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science 353 (6299), pp. 594 - 598 (2016)
  16. Journal Article
    Brown, N. G.; VanderLinden, R.; Watson, E. R.; Weissmann, F.; Ordureau, A.; Wu, K. P.; Zhang, W.; Yu, S.; Mercredi, P. Y.; Harrison, J. S. et al.; Davidson, I. F.; Qiao, R. P.; Lu, Y.; Dube, P.; Brunner, M. R.; Grace, C. R. R.; Miller, D. J.; Haselbach, D.; Jarvis, M. A.; Yamaguchi, M.; Yanishevski, D.; Petzold, G.; Sidhu, S. S.; Kuhlman, B.; Kirschner, M. W.; Harper, J. W.; Peters, J. M.; Stark, H.; Schulman, B. A.: Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C. Cell 165 (6), pp. 1440 - 1453 (2016)
  17. Journal Article
    Qiao, R. P.; Weissmann, F.; Yamaguchi, M.; Brown, N. G.; VanderLinden, R.; Imre, R.; Jarvis, M. A.; Brunner, M. R.; Davidson, I. F.; Litos, G. et al.; Haselbach, D.; Mechtler, K.; Stark, H.; Schulman, B. A.; Peters, J. M.: Mechanism of APC/C-CDC20 activation by mitotic phosphorylation. Proceedings of the National Academy of Sciences of the United States of America 113 (19) (2016)
  18. Journal Article
    Weissmann, F.; Petzold, G.; VanderLinden, R.; in'T Veld, P. J. H.; Brown, N. G.; Lampert, F.; Westermann, S.; Stark, H.; Schulman, B. A.; Peters, J. M.: biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes. Proceedings of the National Academy of Sciences of the United States of America 113 (19) (2016)
  19. Journal Article
    Agafonov, D. E.; Kastner, B.; Dybkov, O.; Hofele, R. V.; Liu, W.; Urlaub, H.; Lührmann, R.; Stark, H.: Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 351 (6280), pp. 1416 - 1420 (2016)
  20. Journal Article
    Stark, H.; Chari, A.: Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy. Microscopy 65 (1), pp. 23 - 34 (2016)
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