Publications of R. Lührmann
All genres
Journal Article (193)
Journal Article
172 (3), pp. 454 - 464, e1-e5 (2018)
Structure and conformational dynamics of the human spliceosomal Bact complex. Cell
Journal Article
23 (12), pp. 1770 - 1779 (2017)
Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing. RNA
Journal Article
31 (23-24), pp. 2416 - 2429 (2017)
The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex. Genes and Development
Journal Article
170 (4), pp. 701 - 713, e1 - e4 (2017)
Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell
Journal Article
45 (7), pp. 4068 - 4080 (2017)
Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2. Nucleic Acids Research
Journal Article
6, e23533 (2017)
Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife
Journal Article
542 (7641), pp. 318 - 323 (2017)
Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature
Journal Article
6, e21510 (2017)
Structural insights into the mechanism of the DEAH-box RNA helicase Prp43. eLife
Journal Article
45 (11), pp. 6729 - 6745 (2017)
SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. Nucleic Acids Research
Journal Article
64 (2), pp. 307 - 319 (2016)
Molecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell
Journal Article
353 (6306), pp. 1399 - 1405 (2016)
Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science
Journal Article
22 (9), pp. 1329 - 1337 (2016)
ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA
Journal Article
22 (9), pp. 1427 - 1440 (2016)
A protein map of the yeast activated spliceosome as obtained by electron microscopy. RNA
Journal Article
7, 11997 (2016)
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications
Journal Article
5, e15564 (2016)
The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife
Journal Article
351 (6280), pp. 1416 - 1420 (2016)
Molecular architecture of the human U4/U6.U5 tri-snRNP. Science
Journal Article
13 (3), pp. 320 - 330 (2016)
Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biology
Journal Article
22 (2), pp. 265 - 277 (2016)
Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA
Journal Article
72 (2), pp. 112 - 120 (2016)
Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F
Journal Article
59 (22), pp. 10190 - 10197 (2016)
Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry